Prevention of Atrial Fibrillation in High-risk Patients Undergoing Lung Cancer Surgery: The PRESAGE Trial

This randomized trial evaluated the efficacy of postoperative metoprolol or losartan in preventing atrial fibrillation in patients with elevated N-terminal pro-brain natriuretic peptide who were undergoing lung resection for cancer.  Among candidates, 29% (320) of patients had elevated NT-proBNP and were randomized.  Both metoprolol and losartan reduced afib incidence compared to controls (6%, 12%, 40%).