Five-Year Outcomes With PCI Guided by Fractional Flow Reserve

Over 1200 patients with stable coronary artery disease and at least one angiographically-significant stenosis were randomized to percutaneous coronary intervention (PCI) plus medical therapy or medical therapy alone for lesions with fractional flow reserve (FFR) <0.8.  FFR-guided PCI was associated with a significantly reduced composite outcome (death, myocardial infarction, or urgent revascularization).  Patients without hemodynamically significant lesions had good outcomes on medical therapy alone.