Extrapleural Pneumonectomy for Malignant Mesothelioma: An Italian Multicenter Retrospective Study

This multicenter retrospective review included 518 pts from 9 centers who underwent EPP from 2000 to 2010.  Half the pts received induction chemotherapy, and nearly three-quarters of the patients received postoperative adjuvant therapy, primarily chemotherapy.  The major surgical complication rate was 26% and 90 day mortality was 6.9%.  3-year survival was 27%.  Factors negatively influencing survival were male sex and non-epithelial histology.  Trimodality treatment with induction therapy was favorably associated with survival.