Surgery Alone Versus Chemoradiotherapy Followed by Surgery for Stage I and II Esophageal Cancer: Final Analysis of Randomized Controlled Phase III Trial FFCD 9901

This randomized trial involving 30 centers in France compared outcomes after induction chemoradiotherapy followed by resection to resection alone for stage I or II esophageal cancer.  The R0 resection rate was similar between the groups.  Postoperative mortality was higher in the induction therapy group (11.1% vs 3.4%).  Long-term survival was similar between the groups.