Antonio Lassaletta

2001 – 2003

Research Assistant, Cell Biology

Principal Investigator. Jill Sible, PhD.

Virginia Polytechnic Institute and State University. Blacksburg, VA.

2004 – 2005

Research Assistant, Cell Biology

Principal Investigator. Claire Moore, MsC, PhD. Tufts University School of Medicine. Boston, MA

2010 – 2012

Research Fellow

Cardiac Surgery

Alpert Medical School of Brown University. Providence, RI

2010 – 2012

Research Fellow

Cardiovascular Behavioral Medicine

Alpert Medical School of Brown University. Providence, RI

Sha W, Moore J, Chen K, Lassaletta AD, Yi C, Tyson JJ, Sible JC. Hysteresis drives cell-cycle transitions in Xenopus laevis egg cell extracts. PNAS. 2003;100(3):975-980

Chu LM, Robich MP, Lassaletta AD, Feng J, Burgess T, Clements R, Sellke FW. Resveratrol supplementation abrogates pro-angiogenic effects of intramyocardial VEGF in a hypercholesterolemic swine model of chronic ischemia. Surgery. 2011;150(3):390-399

Chu LM, Robich MP, Lassaletta AD, Feng J, Xu SH, Heinl R, Liu Y, Sellke E, Sellke FW. High-fat diet alters prostanoid balance and perfusion in ischemic myocardium of naproxen-treated swine. Surgery. 2011;150(3):490-496

Lassaletta AD, Chu LM, Sellke FW. Therapeutic neovascularization for coronary disease: current state and future prospects. Basic Res in Cardiol. 2011;106(6):897-909

Chu LM, Robich MP, Lassaletta A, Burgess T, Liu Y, Sellke N, Sellke FW. Hypercholesterolemia and chronic ischemia alter myocardial responses to selective cyclooxygenase-2 inhibition. J Thorac Cardiovasc Surg. 2011;142(3):675-681

Chu LM, Lassaletta AD, Robich MP, Sellke FW. Resveratrol in the prevention and treatment of coronary artery disease. Curr Atheroscler Rep. 2011;13(6):439-446

Sellke FW, Lassaletta AD, Robich MP, Chu LM, Ruel M. Regenerative therapies for improving myocardial perfusion in patients with cardiovascular disease: failure to meet expectations but optimism for the future. Curr Vasc Pharmacol. 2012;10(3):300-309

Chu, LM, Lassaletta AD, Robich MP, Sellke FW. Resveratrol: Potential benefits on aging and heart disease. Am J Lifestyle Med. 2012;6(5):390-392

Lassaletta AD, Sellke FW. Preserving cardiac and pulmonary function after cardiopulmonary bypass: effects of reactive nitrogen species. Eur J Cardiothorac Surgery. 2012;41(2):396-397

Lassaletta AD, Chu LM, Sellke FW. Effects of alcohol on pericardial adhesion formation in hypercholesterolemic swine. J Thorac Cardiovasc Surg. 2012;143(4):953-959

Lassaletta AD, Chu LM, Robich MP, Burgess TA, Laham RJ, Sturek M, Sellke FW. Overfed Ossabaw swine with early stage metabolic syndrome have normal coronary collateral development in response to chronic ischemia. Basic Res Cardiol. 2012;107(2):1-11

Chu LM, Lassaletta AD, Robich MP, Liu Y, Burgess TA, Laham RJ, Sweeny JD, Shen T, Sellke FW. Effects of red wine and vodka on collateral-dependent perfusion and cardiovascular function in hypercholesterolemic swine. Circulation. 2012;126(11 Suppl 1):S65-72

Lassaletta AD, Chu LM, Elmadhun NY, Burgess TA, Feng J, Sellke FW. Cardioprotective effects of red wine and vodka in a swine model of endothelial dysfunction: decreased oxidative stress and improved microvascular function. J Surg Res. 2012;178(2):586-592

Lassaletta AD, Sellke, FW. Letters to the Editor: Pericardial adhesion reduction with alcohol: unanticipated outcome warrants investigation. J Thorac Cardiovasc Surg. 2012;144(3):739-740

Elmadhun NY, Lassaletta AD, Chu LM, Bianchi C, Sellke FW. Vodka and wine consumption in a swine model of metabolic syndrome alters insulin signaling pathways in the liver and skeletal muscle. Surgery. 2012;152(3):414-422

Elmadhun NY, Lassaletta AD, Chu LM, Liu Y, Feng J, Sellke FW. Atorvastatin increases oxidative stress and modulates angiogenesis in Ossabaw swine with the metabolic syndrome. J Thorac Cardiovasc Surg. 2012;144(6):1486-1493

Lassaletta AD, Chu LM, Elmadhun NY, Hoffman ZG, Kim DJ, Sellke FW. Mechanism for Reduced Pericardial Adhesion Formation in High-fat/cholesterol Fed Pigs Supplemented with Alcohol. Eur J of Cardiothorac Surg. 2013;45(5):1058-1064

Lassaletta AD, Odell D. Diaphragmatic hernias. In: Williams J, Youssef SJ, Williams JA (eds). Thoracic Surgery Residents’ Association Primer of Cardiothoracic Surgery.1^st edition. Chicago, IL: Thoracic Surgery Residents Association. 2013

Lassaletta AD, Elmadhun NY, Sellke FW. Chapter: Quality improvement and surgical checklists. In: Lobdell KW, Stamou SC (eds). Quality Improvement: Methods, Principles and Role in Healthcare. Nova Science. Hauppauge, NY. 2013;  978-1-62417-404-9

Elmadhun NY, Lassaletta AD, Chu LM, Sellke FW. Metformin alters the insulin signaling pathway in ischemic cardiac tissue in a swine model of metabolic syndrome. J Thorac Cardiovasc Surg. 2013; 145(1):258-265. Discussion 265-266

Elmadhun NY, Lassaletta AD, Burgess T, Sabe AA, Sellke FW. Alcohol consumption improves insulin signaling in the myocardium. Surgery. 2013;154(2):320-327

Elmadhun NY, Sabe AA, Robich MP, Chu LM, Lassaletta AD, Sellke FW. The pig as a valuable model for testing the effect of resveratrol to prevent cardiovascular disease. Ann N Y Acad Sci. 2013;1290(1)130-135

Lassaletta AD, Fike FB, Sheth KR. Image of the month. Perforated small-bowel diverticulum with calcified fecalith. JAMA Surg. 2013;148(6):577-578

Lassaletta AD, Elmadhun NY, Liu Y, Feng J, Burgess TA, Karlson NW, Laham RJ, Sellke FW. Ethanol promotes arteriogenesis and restores perfusion to chronically ischemic myocardium. Circulation. 2013;128(26 Suppl 1):S136-143

Lassaletta AD, Elmadhun NY, Zanetti AV, Feng J, Anduaga J, Gohh RY, Sellke FW, Bianchi C. Rapamycin treatment of healthy pigs subjected to acute myocardial ischemia-reperfusion injury attenuates cardiac functions and increases myocardial necrosis. Ann Thorac Surg. 2014;97(3):901-907

Lange M, Koulova, A, Kang S, Griffin MJ, Elmadhun NY, Lassaletta AD, Erat A, Bianchi C, Sellke FW, Usheva A. Arterial-territory specific phosphorylated retinoblastoma protein species and CDK2 promote differences in the vascular smooth muscle cell response to mitogens. Cell Cycle. 2014;13(2):315-323

Lassaletta AD, Elmadhun NY, Burgess TA, Bianchi C, Sabe AA, Robich MP, Chu LM, Sellke FW. Microvascular notch signaling is upregulated in response to vascular endothelial growth factor and chronic myocardial ischemia. Circ J. 2014;78(3):743-751

Elmadhun NY, Sabe AA, Lassaletta AD, Sellke FW. Alcohol consumption mitigates apoptosis and mammalian target of rapamycin signaling in myocardium. J Am Coll Surg. 2014;218(6):1175-1181

Elmadhun NY, Sabe AA, Lassaletta AD, Chu LM, Sellke FW. Metformin mitigates apoptosis in ischemic myocardium. J Surg Res. 2014;192(1):50-58

Elmadhun NY, Sabe AA, Lassaletta AD, Sellke FW. Ethanol promotes new vessel growth in remote nonischemic myocardium. J Surg Res. 2015;193(2):536-542

Elmadhun NY, Sabe AA, Lassaletta AD, Chu LM, Kondra K, Sturek M, Sellke, FW. Metabolic syndrome impairs Notch signaling and promotes apoptosis in chronically ischemic myocardium. J Thorac Cardiovasc Surg. 2014;148(3):1048-1055

Elmadhun NY, Sadek AA, Sabe AA, Lassaletta AD, Sellke FW. Alcohol and the heart: A proteomics analysis of pericardium and myocardium in a swine model of myocardial ischemia. Ann Thorac Surg. 2015;100(5):1627-1635

Saraf R, Huang T, Mahmood F, Owais K, Bardia A, Khabbaz KR, Liu D, Senthilnathan V, Lassaletta AD, Sellke F, Matyal R. Early cellular changes in the ascending aorta and myocardium in a swine model of metabolic syndrome. PLoS One. 2016;11(1):e0146481

Lassaletta AD, Laham RJ, Pinto DS, Pleskow DK, Sawhney MS, Chuttani R, Kent MS. Successful closure of an esophagopleural fistula with an Amplatzer occluder sealed with liquid copolymer, with 3 year follow up and review of literature. Pleura. 2016;3:1-6

2003

Bachelor of Science

Mechanical Engineering

Virginia Polytechnic Institute and State University. Blacksburg, VA

2007

Medical Doctorate

Medicine

Tufts University School of Medicine. Boston, MA

2007 - 2010

2012 - 2015

Clinical Fellow

Surgery

Harvard Medical School. Boston, MA

2007 - 2008

Intern

General Surgery

Beth Israel Deaconess Medical Center. Boston, MA

2007 - 2010

2012 - 2014

Resident

General Surgery

Beth Israel Deaconess Medical Center. Boston, MA

2014 - 2015

Chief Resident

General Surgery

Beth Israel Deaconess Medical Center. Boston, MA

2010 - 2012

Research Fellow

Cardiac Surgery

Alpert Medical School of Brown University. Providence, RI

2010 - 2012

Research Fellow

Cardiovascular Behavioral Medicine

Alpert Medical School of Brown University. Providence, RI

2015 -

Clinical Fellow

Cardiothoracic Surgery

Harvard Medical School. Beth Israel Deaconess Medical Center. Boston, MA