David Francischelli
Industry Representative
BioScience Innovations
About
Innovative, results-driven research and development leader with a progressive technical leadership career in the medical device industry. Served on executive leadership teams with a record of excellence in large and small public companies. Broad background in life sciences, engineering, and business. Ability to “connect the dots,” and identify dots that others may not even see. Known for technical rigor and delivering life-changing medical devices to the market. Whether envisioning new techniques or therapies, running clinical trials, patenting and commercializing devices, or transforming teams, consistently deliver positive impacts to the bottom line for patients, customers and the organization.
Research
Slater D, Foley J, Phillips L, Francischelli D. Band occlusion of the atrial appendage. J Card Surg. 2010;25(2):156-160.
McCarthy P, Lee R, Foley J, Kanayinkal T, Phillips L, Francischelli D. Occlusion of canine atrial appendage using an expandable silicone band. JTCVS. 2010;140:885-9.
Werner J, Lee H, Park EJ, Francischelli D, Smith N. Feasibility of in vivo transesophageal cardiac ablation using a phased ultrasound array. Ultrasound Med Biol. 2010;36(5):752-60.
Lee H, Francischelli D, Smith N. Design of focused ultrasound array for non-invasive transesophageal cardiac ablation. Open Med Device J. 2010;2:51-60.
Francischelli D. Irrigated radiofrequency – biophysics and application to surgical ablation. Innovations. 2009;4(5):294-6.
Hong J, Stewart MT, Cheek DS, Francischelli DE, Kirchhof N. Cardiac ablation via electroporation. Conf Proc IEEE Eng Med Biol Soc. 2009;1:3381-4.
Ahlberg SE, Hong J, Stewart MT, Francischelli DE, Kress DC. Exit vs. entrance block testing for cardiac lesion assessment. Conf Proc IEEE Eng Med Biol Soc. 2009;1:3282-5.
Ota T, Schwartzman D, Francischelli D, Hettrick D, Zenati M. Impact of beating heart left atrial ablation on left-sided heart mechanics. JTCVS 134(4):982-8, 2007.
Lee H, Francischelli D, Smith N. The Feasibility of Transesophageal Cardiac Ablation by Focused Ultrasound. AIP Conf Proc. May 21, 2007; 911:104-110.
Hamner C, Potter D, Kwang, Lutterman A, Francischelli D, Sundt T, Schaff H. Irrigated Radiofrequency Ablation With Transmurality Feedback Reliably Produces Cox Maze Lesions In Vivo. Ann Thorac Surg. 80:2263-70, 2005.
Hamner C, Lutterman A, Potter D, Sundt T, Schaff H, Francischelli D. Irrigated bipolar radiofrequency ablation with transmurality feedback for the surgical Cox-Maze procedure. Heart Surg Forum. 6(5):418-23, 2003.
Bonanomi G, Schwartzman D, Francischelli D, Hebsgaard K, Zenati M. A new device for beating heart bipolar radiofrequency atrial ablation. J Thorac Cardiovasc Surg. 126(6):1859-66, 2003.
Letsou GV, Zarif A, Hogan JF, Miller CC, Elefteriades JA, Francischelli DE, Safi HJ: Physiologic characteristics of canine skeletal muscle; Implications for timing skeletal muscle cardiac assist devices. Ann. Thorac Surg. 72(4):1336-42, 2001.
Caccitollo J, Francischelli D, Stulak J, Jensen D, Mehra R, Schaff H: Open Heart Endocardial Radio Frequency Ablation as an Alternative to Incisions in Creating an Atrial Maze. J Surg Res. 97, p23-33, 2001.
Checkanov V, Deshponde S, Francischelli D, Werner P, Waller D, Schmidt D: Cardiomyoplasty After Implantation of a Pacemaker and Implantable Cardioverter/Defibrillator. Ann Thorac Surg, 66:3, p954-6, 1998.
Chekanov V, Nikolaychik V, Rieder M, Tchekanov G, Hernandez I, Eisenstein R, Francischelli D, Lelkes P, Schmidt D. Autologous Biological Glue and Aprotinin Prevent Ischemia in Latissimus Dorsi Muscle after Mobilization. Basic Appl. Myol. 8 (3):211-219, 1998.
Mott BD, Oh JH, Misawa Y, Helou J, Badhwar V, Francischelli D, Chiu RCJ: Mechanisms of Cardiomyoplasty: Comparative Effects of Adynamic verses Dynamic Cardiomyoplasty. Ann Thorac Surg, 65, p1039-45, 1998.
Gealow K, Francischelli D, Solien E, Grandjean P: Alternative training protocols for cardiomyoplasty. BAM, 7:1, p31-38, 1997.
Francischelli DE, Peterson DK, Stein PM, Gealow, KK, Grandjean PA: Cardiomyoplasty and Defibrillator: A Combined Treatment for Heart Failure. In Cardiac Bioassist: Carpentier A, Chachques JC, Grandjean PA (eds). Futura Publishing, Inc. Armonk, NY, 1997, pp 417-28.
Francischelli DE, Peterson DK, Stein PM, Gealow, KK, Struble C, Grandjean PA: Combined cardiomyoplasty and anti-tachyarrhythmia therapies. PACE, 18:4:II, p800, 1995.
Mott BD, Misawa Y, Helou J, Francischelli D, Chiu RC-J: Effects of adynamic cardiomyoplasty on ventricular function in a rapid pacing heart failure model. J Molec & Cell Cardiol, 27:5, pA12, May 1995.
Francischelli DE, Gealow KC, Cerkvenik J, Grandjean PA: Combined cardiomyoplasty/DDD-bradycardia therapies. ASAIO, 1994.
Letsou GV, Zarif A, Higgins RSD, Liu WX, Smith A, Francischelli D, Condos S, Ariyan S, Baldwin JC, Elefteriades JA: Power generating capacity of skeletal muscle ventricles (SMVs) is dependent on pre-load and stimulation frequency. FASEB J 7:A462:2680, 1993.
Zarif A, Liu WX, Smith A, Francischelli D, Condos S, Ariyan S, Baldwin JC, Elefteriades JA, Letsou GV: Time to peak pressure in unconditioned skeletal muscle ventricles (SMVs) is related to stimulation frequency and pre-load. FASEB J 7:A462:2681, 1993.
Letsou GV, Zarif A, Higgins RSD, Liu WX, Smith A, Francischelli D, Condos S, Ariyan S, Baldwin JC, Elefteriades JA: Pressure generating capacity of conditioned skeletal muscle ventricles is less than conditioned skeletal muscle ventricles, and is dependent on pre-load and stimulation frequency. World Symposium on Cardiomyoplasty, Biomechanical Assist, and Artificial Heart, May 24-26, 1993.
Francischelli DE, Tarbell JM, Geselowitz DB: Local blood residence times in the Penn State Artificial Heart. Artificial Organs 15(3):218-224, 1991.
Francischelli DE: A fiber-optic technique to determine fluid residence times and washout patterns in the Penn State Artificial Heart. Master's thesis. Penn State University. 1989.
Francischelli DE, Tarbell JM, Deutsch S, Geselowitz DB: A fiber-optic technique to determine blood residence times and washout patterns in the Penn State Artificial Heart. Proc of the 15th Annual Northeast Bioengineering Conf 81-82, 1989.
Baldwin JT, Francischelli DE, Tarbell JM, Geselowitz DB: Fluid mechanics of the Penn State Artificial Heart: LDA and dye washout studies. The Third Joint ASCE/ASME Biomechanics Symp AMD-Vol 98:257-260, 1989
Tarbell JM, Baldwin JT, Jarvis P, Francischelli DE, Frangos JA, Deutsch S, Geselowitz DB: Fluid mechanics and cellular interaction in the Penn State Artificial Heart. Proc ASME Bioprocess Engineering Symp. 15-19, 1989.
Additional Education Information
Executive Leadership Program
University of Pennsylvania – The Wharton School, Philadelphia, PA
MBA - New Venture Management
The University of Saint Thomas, St. Paul, MN
Master of Science - Bioengineering
The Pennsylvania State University, University Park, PA
Bachelor of Arts - Biology
Saint Michael's College, Colchester, VT
Practice Areas
None
Organizations
Other Interests
· Innovation / Brainstorming
· Opportunity Assessments
· Strategy Development
· Competitive Intelligence
· Merger & Acquisition
· Team Building / Leadership
· Staff Development / Training
· Coaching for Performance
· Product Lifecycle Management
· Technology Roadmapping
· Intellectual Property Strategy
· Clinical Trial Strategy