Jussuf Kaifi

Translational cancer research on liquid biomarkers: 

Recent publications (selected out of >125 PubMed-listed articles): 

1. Suvilesh KN, Nussbaum YI, Radhakrishnan V, Manjunath Y, Avella DM, Staveley-O’Carroll KF, Kimchi ET, Chaudhuri AA, Shyu CR, Li G, Pantel K, Warren WC, Mitchem JB, Kaifi JT. Tumorigenic circulating tumor cells from xenograft mouse models of non-metastatic NSCLC patients reveal distinct single cell heterogeneity and drug responses. Molecular Cancer. 2022.
2. Manjunath Y, Suvilesh KN, Mitchem JB, Avella DM, Kimchi ET, Staveley-O’Carroll KF, Pantel K, Yi H, Li G, Chaudhuri AA, Kaifi JT. Circulating tumor-macrophage fusion cells and circulating tumor cells complement non-small cell lung cancer screening in subjects with suspicious Lung-RADS4 nodules. JCO Precision Oncology. 2022.
3. Manjunath Y, Mitchem JB, Suvilesh KN, Avella DM, Kimchi ET, Staveley-O’Carroll KF, Deroche CB, Pantel K, Li G, Kaifi JT. Circulating giant tumor-macrophage fusion cells are independent prognosticators in non-small cell lung cancer patients. J Thorac Oncol. 2020. 
4. Kumar SR, Kimchi ET, Manjunath Y, Gajagowni S, Stuckel AJ, Kaifi JT. RNA cargos in extracellular vesicles derived from blood serum in pancreas associated conditions. Sci Rep 2020 10:2800. 
5. Avella DM, Manjunath Y, Singh A, Deroche CB, Kimchi ET, Staveley-O’Carroll KF, Mitchem JB, Kwon E, Li G, Kaifi JT. 18F-FDG PET/CT total lesion glycolysis is associated with circulating tumor cell counts in patients with stage I – IIIA non-small cell lung cancer. Transl Lung Cancer Res. 2020
6. Manjunath Y, Upparahalli SV, Suvilesh KN, Avella DM, Kimchi ET, Staveley-O’Carroll KF, Li G, Kaifi JT. Circulating tumor cell clusters are a potential biomarker for detection of non-small cell lung cancer. Lung Cancer. 2019
7. Manjunath Y, Upparahalli SV, Avella DM, Deroche C, Kimchi ET, Staveley-O’Carroll KF, Smith C, Li G, Kaifi JT. PD-L1 expression with epithelial-mesenchymal transition of circulating tumor cells is associated with poor survival in curatively resected non-small cell lung cancer. Cancers; 2019

Clinical trials:

site-PI for the Lung Cancer Mutation Consortium (LCMC)-4 neoadjuvant screening trial for evaluation of actionable drivers in early stage lung cancer

PI for ongoing translational, observational clinical trials: NCT02838836, NCT03551951

Associate Editor for the Society for University Surgeons (SUS), Surgery, 2019-2022