Concordance Between Comprehensive Cancer Genome Profiling in Plasma and Tumor Specimens

The authors demonstrated substantial concordance between sequencing of 39 genes in a liquid assay and routine diagnostic testing in tissue in 82 patients.  Agreement was 98%, and the primary reason for failure was low levels of circulating DNA in the plasma.  Sensitivity was 70%, and specificity was 100%.  The system offers accurate identification of driver mutations in plasma of patients with NSCLC.