First-in-Human Transapical Beating-Heart Septal Myectomy in Patients with Hypertrophic Obstructive Cardiomyopathy

This paper reports the first in-human trial exploring surgical reduction therapy for hypertrophic obstructive cardiomyopathy (HOCM). Patients recruited to the trial were those who presented with refractory HOCM with disabling symptoms despite best medical management. The authors reported on the procedural success of a novel transapical beating heart septal myectomy via a minithoracotomy under echocardiographic guidance.