Outcome of surgery versus radiotherapy after induction treatment in patients with N2 disease: systematic review and meta-analysis of randomised trials

This meta-analysis evaluated results from 6 studies totalling 868 patients randomized to local control (radiotherapy vs surgery) after induction therapy for NSCLC with N2 disease.  Four studies evaluated induction chemotherapy, the other 2 evaluated induction chemoradiotherapy.  Differences in outcomes were not significant, but there was a strong trend favoring surgery as part of multimodality therapy for NSCLC with N2 disease.