Procedural Outcomes of Pulmonary Atresia with Intact Ventricular Septum in Neonates: A Multicenter Study

This analysis of 279 neonates with pulmonary atresia and intact ventricular septum who underwent surgical or catheter intervention between 2009 and 2019 in nineteen centers showed that seventy-nine (28 percent) underwent right ventricular decompression, 151 (54 percent) underwent systemic-to-pulmonary shunt or ductal shunt only, thirty-six (13 percent) underwent both, and eleven (4 percent) received transplants. Major adverse events—including in-hospital mortality (8 percent), cardiopulmonary resuscitation (13 percent), stroke (6 percent), and mechanical circulatory support (13 percent)—were reported in fifty-seven patients (20 percent). Lower weight and the presence of two major coronary stenoses predicted major adverse events, and the authors recommend vigilance in procedural planning in patients with these risk factors.