Spread Through Air Spaces is an Independent Predictor of Recurrence in Stage III (N2) Lung Adenocarcinoma

Spread through air space (STAS) is a pattern of lung adenocarcinoma invasion, and it is a predictor of recurrence in patients with early-stage lung adenocarcinoma. However, less is known about the role of STAS in advanced lung adenocarcinoma. In this retrospective study including 76 patients with stage III lung adenocarcinoma, the presence of a STAS invasion pattern was a significant risk factor for adenocarcinoma relapse.