The Value of Circulating Biomarkers in Bicuspid Aortic Valve-Associated Aortopathy

Size-based parameters have both value and limitations in predicting the risk of aortopathy in patients with bicuspid aortic valves. Given the limitations of these morphological predictive tools, Naito and colleagues review the potential of biomarkers to assess aortic disease in these patients. The authors discuss evidence for markers that are more routinely available for testing, such as MMPs, TIMPs, and alpha 1-antitrypsin, as well as those markers that are primarily experimental.